The rate and extent of drug absorption from a dosage form.
The rate processes involved in the absorption, distribution, metabolism, and excretion of drugs.
Absorption, Distribution, Metabolism, Excretion.
The relationship between drug concentration at the site of action and the pharmacologic response.
A substance that binds to and activates a receptor, producing maximal biological response.
A substance that binds to and activates a receptor but does not produce a maximal response.
A substance that binds to a receptor but does not activate it, competing with agonists for receptor binding.
It induces an effect opposite to that of an agonist and reduces the constitutive activity of the receptor.
Absorption.
In IV administration, there is no absorption, resulting in 100% bioavailability.
Small intestine.
pH = pK_a + log ( [A^-] / [HA] )
Acidic drugs are non-ionized.
Body position can influence GER.
Fatty meals decrease absorption except for certain drugs.
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Explore the key concepts of pharmacokinetics and pharmacodynamics, focusing on drug absorption, distribution, metabolism, and excretion, as well as their implications in anesthesia and pain management.
1. What does pharmacokinetics study?
2. Which of the following accurately describes a full agonist?
3. What is the main site for drug absorption in the gastrointestinal tract?
4. What does bioavailability refer to?
5. Which drug undergoes first-pass effect and has rapid hepatic metabolism?
6. What is the primary function of albumin in drug distribution?
7. Which phase of drug metabolism involves oxidation, reduction, deamination, and hydrolysis?
8. Which of the following is a characteristic of a neutral antagonist?
9. Which part of the gastrointestinal tract has the largest surface area for drug absorption?
10. What effect does lying on the right side have on gastric emptying rate (GER)?
This document provides an integrated overview of pharmacokinetics and pharmacodynamics as they relate to anesthesia, highlighting the mechanisms of drug action, absorption, and their implications for patient care during surgical procedures.
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